PNC-27 is a 32-residue chimeric peptide derived from the p53 tumor suppressor protein. Engineered to bind specifically to HDM-2 (also known as MDM2), a protein overexpressed on the membranes of many cancer cells, PNC-27 initiates transmembrane pore formation that leads to rapid necrosis in malignant cells—while sparing healthy tissue. It is widely studied in models of pancreatic, breast, melanoma, and leukemia cancers.
Key Benefits:
Selective Cytotoxicity: Targets HDM-2 on cancer cell membranes, inducing cell death without harming normal cells.
Pore Formation Mechanism: Disrupts membrane integrity through peptide-induced pore formation, leading to necrosis.
Broad Tumor Line Applicability: Studied across multiple solid tumor types including pancreatic, breast, and melanoma.
Immunotherapeutic Potential: Explored as a safer alternative to chemotherapy or radiotherapy in preclinical models
🔬 Research Use Only:
This product is intended for Research purposes only.