Overview
KPV (Lys‑Pro‑Val) is a naturally occurring tripeptide derived from the C‑terminal region of alpha‑melanocyte‑stimulating hormone (α‑MSH). It is widely utilized in in vitro and laboratory‑based research involving immune‑signaling pathways, epithelial biology, and cytokine‑modulation mechanisms. KPV is of particular interest for studies examining non‑pigmenting peptide fragments associated with inflammatory‑response regulation.
Molecular Characteristics
Peptide Type: α‑MSH–derived tripeptide fragment
Form: Lyophilized powder
Purity: ≥ 98% (HPLC)
Storage: –20°C recommended
Research Applications
KPV is commonly investigated in controlled laboratory environments for:
Cytokine‑signaling pathway analysis
NF‑κB‑related biochemical studies
In vitro modeling of epithelial and barrier‑response mechanisms
Assay development involving immune‑modulation pathways
Exploration of non‑melanogenic α‑MSH fragments
 
Mechanistic Notes (Research Context Only)
In laboratory settings, KPV is studied for its interaction with:
NF‑κB and pro‑inflammatory signaling pathways
Cytokine‑expression regulatory mechanisms
Epithelial‑cell response models under stress conditions
Non‑pigmenting melanocortin‑related pathways
These statements describe mechanistic interest, not biological effects in humans or animals.
Storage & Handling
Store lyophilized peptide at –20°C
Avoid repeated freeze–thaw cycles
Handle reconstituted solutions according to laboratory best practices
Important Research Notice
For laboratory research use only
Not for human consumption
Not a drug, food, or cosmetic
Not for veterinary or household use
No medical or therapeutic claims are made